MolNFT v1 · #81309 · protein

SCFV12, anti-bcla antibody single chain variable fragment

3UMT · Scfv heavy chain and light chain: “SCFV12, anti-bcla antibody single chain variable fragment”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #81309 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UMT
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Scfv heavy chain and light chain
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Scfv heavy chain and light chain	protein	227	7% helix, 49% strand	—

Ligands and binding sites

NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.29	0.73	13	empty
2	53	0.28	0.74	16	NHE

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3UMT · scFv12, Anti-BclA antibody single chain variable fragment · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3UMT · PDBe 3UMT

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