MolNFT v1 · #81288 · protein
Crystal structure of the human two pore domain K+ ion channel traak (K2P4.1)
3UM7 · Potassium channel subfamily K member 4: “Crystal structure of the human two pore domain K+ ion channel traak (K2P4.1)”. X-ray diffraction, 1 ligand (K), 7 pockets (best druggability 0.74). MolNFT v1 #81288 on GenesisL1: 3D…
- PDB
- 3UM7
- Type
- protein
- Length
- 503 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel subfamily K member 4
- UniProt
- Q9NYG8
- Ligands
- K
- Pockets
- 7 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium channel subfamily K member 4 | protein | 259 | 68% helix, 0% strand | Q9NYG8 |
| B | Potassium channel subfamily K member 4 | protein | 244 | 66% helix, 0% strand | Q9NYG8 |
Ligands and binding sites
- K · Potassium ion · metal · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1083 | 0.74 | 0.77 | 103 | K |
| 2 | 872 | 0.71 | 0.75 | 58 | empty |
| 3 | 52 | 0.66 | 0.94 | 13 | empty |
| 4 | 71 | 0.44 | 0.80 | 15 | empty |
| 5 | 60 | 0.30 | 0.73 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 2172 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3UM7 · Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1) · the same entry in another collection · chain B against B, TM-score 1.00
- Q9NYG8 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 4 (Q9NYG8) · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NYG8
- Elsewhere: RCSB PDB 3UM7 · PDBe 3UM7 · UniProt Q9NYG8
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