MolNFT v1 · #81241 · protein
Structure of the C-LINKER/CNBHD of zelk channels in P 1 21 1 space group, crystallized in the presence of camp
3UKV · Novel protein similar to vertebrate potassium voltage-gated…: “Structure of the C-LINKER/CNBHD of zelk channels in P 1 21 1 space group, crystallized in the presence of camp”. X-ray diffraction, 5 pockets (best druggability 0.83).…
- PDB
- 3UKV
- Type
- protein
- Length
- 703 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H…
- UniProt
- A8WHX9
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 196 | 40% helix, 21% strand | A8WHX9 |
| A | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 195 | 42% helix, 24% strand | A8WHX9 |
| C | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 193 | 39% helix, 22% strand | A8WHX9 |
| D | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 119 | 29% helix, 24% strand | A8WHX9 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.83 | 0.84 | 126 | empty |
| 2 | 1089 | 0.73 | 0.76 | 89 | empty |
| 3 | 89 | 0.48 | 0.82 | 23 | empty |
| 4 | 60 | 0.31 | 0.75 | 12 | empty |
| 5 | 57 | 0.26 | 0.72 | 11 | empty |
Interfaces
4 interfaces between chains.
- B–A · 1314 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 770 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 300 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 261 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3UKV · Structure of the C-linker/CNBHD of zELK channels in P 1 21 1 space group, crystallized in… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8WHX9
- Elsewhere: RCSB PDB 3UKV · PDBe 3UKV · UniProt A8WHX9
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