MolNFT v1 · #81234 · protein
Structure of the C-LINKER/CNBHD of zelk channels in C 2 2 21 space group
3UKN · Novel protein similar to vertebrate potassium voltage-gated…: “Structure of the C-LINKER/CNBHD of zelk channels in C 2 2 21 space group”. X-ray diffraction, 5 pockets (best druggability 0.83). MolNFT v1 #81234 on GenesisL1: 3D…
- PDB
- 3UKN
- Type
- protein
- Length
- 580 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H…
- UniProt
- A8WHX9
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 196 | 41% helix, 23% strand | A8WHX9 |
| B | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 198 | 41% helix, 24% strand | A8WHX9 |
| C | Novel protein similar to vertebrate potassium voltage-gated channel, subfamily H (eag-related) family | protein | 186 | 36% helix, 20% strand | A8WHX9 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 871 | 0.83 | 0.85 | 98 | empty |
| 2 | 185 | 0.63 | 0.83 | 25 | empty |
| 3 | 83 | 0.35 | 0.75 | 23 | empty |
| 4 | 50 | 0.28 | 0.75 | 11 | empty |
| 5 | 55 | 0.28 | 0.74 | 11 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1291 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 387 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 127 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3UKN · Structure of the C-linker/CNBHD of zELK channels in C 2 2 21 space group · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8WHX9
- Elsewhere: RCSB PDB 3UKN · PDBe 3UKN · UniProt A8WHX9
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