MolNFT v1 · #81026 · protein
Crystal structure of human survivin H80A mutant
3UEH · Baculoviral iap repeat-containing protein 5: “Crystal structure of human survivin H80A mutant”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.52). MolNFT v1 #81026 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3UEH
- Type
- protein
- Length
- 274 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Baculoviral iap repeat-containing protein 5
- UniProt
- O15392
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Baculoviral iap repeat-containing protein 5 | protein | 137 | 55% helix, 7% strand | O15392 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains A, B
- PGE · Triethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 123 | 0.52 | 0.81 | 20 | empty |
| 2 | 99 | 0.49 | 0.81 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 559 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15392
- Elsewhere: RCSB PDB 3UEH · PDBe 3UEH · UniProt O15392
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