MolNFT v1 · #80856 · protein
Crystal structure of oxidized human FBXL5 hemerythrin like domain
3U9J · F-BOX/LRR-repeat protein 5: “Crystal structure of oxidized human FBXL5 hemerythrin like domain”. X-ray diffraction, 1 ligand (FE), 2 pockets (best druggability 0.70). MolNFT v1 #80856 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3U9J
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-BOX/LRR-repeat protein 5
- UniProt
- Q9UKA1
- Ligands
- FE
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | F-BOX/LRR-repeat protein 5 | protein | 157 | 82% helix, 0% strand | Q9UKA1 |
Ligands and binding sites
- FE · Fe (III) ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 587 | 0.70 | 0.79 | 52 | empty |
| 2 | 60 | 0.35 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 835 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3U9J · Crystal structure of oxidized human FBXL5 hemerythrin like domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UKA1 · AlphaFold monomer V2.0 prediction for F-BOX/LRR-repeat protein 5 (Q9UKA1) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKA1
- Elsewhere: RCSB PDB 3U9J · PDBe 3U9J · UniProt Q9UKA1
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