MolNFT v1 · #80626 · protein

Neutron crystal structure of human transthyretin

3U2J: “Neutron crystal structure of human transthyretin”. Neutron diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #80626 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3U2J
Type: protein
Length: 225 residues
Chains: 2
Method: neutron diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: P02766
Pockets: 1 · best druggability 0.31

Structure

neutron diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transthyretin	protein	115	5% helix, 51% strand	P02766
B	Transthyretin	protein	110	6% helix, 52% strand	P02766

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.31	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 913 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

3U2J · Neutron crystal structure of human Transthyretin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02766
Elsewhere: RCSB PDB 3U2J · PDBe 3U2J · UniProt P02766

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