Atomic resolution crystal structure of the 2ND SH3 domain from human CD2AP (cms) in complex with a proline-rich peptide from human RIN3

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 45% strand (DSSP).

Ligands and binding sites

• NH2 · Amino group · ion · chains B
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 619 Ų buried · 8 hydrogen bonds · protein-protein

Compared structures

• 3U23 · Atomic resolution crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y5K6 · AlphaFold monomer V2.0 prediction for CD2-associated protein (Q9Y5K6) · a predicted model of the same protein · chain A against A, TM-score 0.95
• Q8TB24 · AlphaFold monomer V2.0 prediction for RAS and rab interactor 3 (Q8TB24) · a predicted model of the same protein · chain B against A, TM-score 0.41

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y5K6
• Every structure of UniProt Q8TB24
• Elsewhere: RCSB PDB 3U23 · PDBe 3U23 · UniProt Q9Y5K6 · UniProt Q8TB24