MolNFT v1 · #80575 · protein
Tetramerization dynamics of the C-terminus underlies isoform-specific camp-gating in hcn channels
3U0Z · POTASSIUM/SODIUM hyperpolarization-activated cyclic…: “Tetramerization dynamics of the C-terminus underlies isoform-specific camp-gating in hcn channels”. X-ray diffraction, 1 ligand (CMP), 6 pockets (best druggability 0.73). MolNFT…
- PDB
- 3U0Z
- Type
- protein
- Length
- 398 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 1
- UniProt
- O88704
- Ligands
- CMP
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 1 | protein | 199 | 52% helix, 18% strand | O88704 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.73 | 0.93 | 20 | CMP |
| 2 | 130 | 0.71 | 0.91 | 21 | CMP |
| 3 | 292 | 0.54 | 0.75 | 28 | empty |
| 4 | 216 | 0.51 | 0.76 | 27 | empty |
| 5 | 248 | 0.50 | 0.75 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 285 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3U0Z · Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN… · the same entry in another collection · chain A against A, TM-score 1.00
- O88704 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88704
- Elsewhere: RCSB PDB 3U0Z · PDBe 3U0Z · UniProt O88704
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