MolNFT v1 · #80311 · protein

4-coumaroyl-CoA LIGASE::STILBENE synthase fusion protein

3TSY · Fusion protein 4-coumarate--CoA ligase 1, resveratrol…: “4-coumaroyl-CoA LIGASE::STILBENE synthase fusion protein”. X-ray diffraction, 5 pockets (best druggability 0.74). MolNFT v1 #80311 on GenesisL1: 3D structure, binding sites…

PDB: 3TSY
Type: protein
Length: 828 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion protein 4-coumarate--CoA ligase 1, resveratrol synthase
EC: 6.2.1.12, 2.3.1.95
UniProt: Q42524, Q2HY10
Pockets: 5 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fusion protein 4-coumarate--CoA ligase 1, resveratrol synthase (EC 6.2.1.12, 2.3.1.95)	protein	828	36% helix, 23% strand	Q42524, Q2HY10

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.74	0.85	46	empty
2	381	0.60	0.76	56	empty
3	71	0.33	0.75	15	empty
4	78	0.31	0.73	14	empty
5	53	0.25	0.73	13	empty

Compared structures

3TSY · 4-Coumaroyl-CoA Ligase::Stilbene Synthase fusion protein · the same entry in another collection · chain A against A, TM-score 1.00
Q42524 · AlphaFold monomer V2.0 prediction for 4-coumarate--CoA ligase 1 (Q42524) · a predicted model of the same protein · chain A against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q42524
Every structure of UniProt Q2HY10
Elsewhere: RCSB PDB 3TSY · PDBe 3TSY · UniProt Q42524 · UniProt Q2HY10

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.