MolNFT v1 · #80190 · protein

The phipa P3121 structure

3TPE · SERINE/THREONINE-protein kinase hipa: “The phipa P3121 structure”. X-ray diffraction, 2 pockets (best druggability 0.85). MolNFT v1 #80190 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3TPE
Type: protein
Length: 421 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase hipa
EC: 2.7.11.1
UniProt: P23874
Pockets: 2 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase hipa (EC 2.7.11.1)	protein	421	39% helix, 21% strand	P23874

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	694	0.85	0.88	69	empty
2	90	0.41	0.78	16	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

3TPE · The phipa p3121 structure · the same entry in another collection · chain A against A, TM-score 1.00
P23874 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase toxin hipa (P23874) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23874
Elsewhere: RCSB PDB 3TPE · PDBe 3TPE · UniProt P23874

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