MolNFT v1 · #80164 · protein
Crystral structure of the C-terminal subunit of human maltase- glucoamylase
3TON · Maltase-glucoamylase, intestinal: “Crystral structure of the C-terminal subunit of human maltase- glucoamylase”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #80164 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3TON
- Type
- protein
- Length
- 1,780 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltase-glucoamylase, intestinal
- EC
- 3.2.1.20, 3.2.1.3
- UniProt
- O43451
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Maltase-glucoamylase, intestinal (EC 3.2.1.20, 3.2.1.3) | protein | 890 | 22% helix, 27% strand | O43451 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.77 | 0.93 | 27 | empty |
| 2 | 67 | 0.74 | 0.98 | 21 | empty |
| 3 | 66 | 0.74 | 0.98 | 20 | empty |
| 4 | 269 | 0.69 | 0.84 | 42 | empty |
| 5 | 263 | 0.68 | 0.83 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 632 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3TON · Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase · the same entry in another collection · chain A against A, TM-score 1.00
- O43451 · AlphaFold monomer V2.0 prediction for maltase-glucoamylase, intestinal (O43451) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43451
- Elsewhere: RCSB PDB 3TON · PDBe 3TON · UniProt O43451
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