MolNFT v1 · #80151 · protein
Human mof crystal structure with active site lysine partially acetylated
3TOA · Histone acetyltransferase MYST1: “Human mof crystal structure with active site lysine partially acetylated”. X-ray diffraction, 2 ligands (ZN, CL), 2 pockets (best druggability 0.67). MolNFT v1 #80151 on GenesisL1: 3D structure…
- PDB
- 3TOA
- Type
- protein
- Length
- 265 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase MYST1
- EC
- 2.3.1.48
- UniProt
- Q9H7Z6
- Ligands
- ZN, CL
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase MYST1 (EC 2.3.1.48) | protein | 265 | 36% helix, 25% strand | Q9H7Z6 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.67 | 0.87 | 32 | EDO |
| 2 | 57 | 0.35 | 0.78 | 16 | empty |
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 3TOA · Human MOF crystal structure with active site lysine partially acetylated · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H7Z6 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT8 (Q9H7Z6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H7Z6
- Elsewhere: RCSB PDB 3TOA · PDBe 3TOA · UniProt Q9H7Z6
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