MolNFT v1 · #80149 · protein
Crystal structure of the two C-terminal rrm domains of heterogeneous nuclear ribonucleoprotein L (hnrnp L)
3TO8: “Crystal structure of the two C-terminal rrm domains of heterogeneous nuclear ribonucleoprotein L (hnrnp L)”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.40). MolNFT v1 #80149 on GenesisL1: 3D structure, binding…
- PDB
- 3TO8
- Type
- protein
- Length
- 209 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heterogeneous nuclear ribonucleoprotein L
- UniProt
- P14866
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heterogeneous nuclear ribonucleoprotein L | protein | 209 | 22% helix, 27% strand | P14866 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.40 | 0.82 | 15 | empty |
| 2 | 59 | 0.28 | 0.74 | 17 | empty |
Compared structures
- 3TO8 · Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear… · the same entry in another collection · chain A against A, TM-score 1.00
- P14866 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein L (P14866) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14866
- Elsewhere: RCSB PDB 3TO8 · PDBe 3TO8 · UniProt P14866
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