MolNFT v1 · #80049 · protein
The avrptob-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III effector
3TL8 · Brassinosteroid insensitive 1-associated receptor kinase 1: “The avrptob-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III…”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT…
- PDB
- 3TL8
- Type
- protein
- Length
- 1,576 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Brassinosteroid insensitive 1-associated receptor kinase 1; Effector protein HOPAB2
- EC
- 2.7.10.1, 2.7.11.1, 6.3.2.-
- UniProt
- Q94F62, Q8RSY1
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 47% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Brassinosteroid insensitive 1-associated receptor kinase 1 (EC 2.7.10.1, 2.7.11.1) | protein | 304 | 43% helix, 16% strand | Q94F62 |
| B | Effector protein HOPAB2 (EC 6.3.2.-) | protein | 87 | 62% helix, 1% strand | Q8RSY1 |
| D | Brassinosteroid insensitive 1-associated receptor kinase 1 (EC 2.7.10.1, 2.7.11.1) | protein | 310 | 43% helix, 16% strand | Q94F62 |
| F, K | Effector protein HOPAB2 (EC 6.3.2.-) | protein | 88 | 63% helix, 1% strand | Q8RSY1 |
| G | Brassinosteroid insensitive 1-associated receptor kinase 1 (EC 2.7.10.1, 2.7.11.1) | protein | 305 | 43% helix, 16% strand | Q94F62 |
| H | Brassinosteroid insensitive 1-associated receptor kinase 1 (EC 2.7.10.1, 2.7.11.1) | protein | 307 | 43% helix, 16% strand | Q94F62 |
| L | Effector protein HOPAB2 (EC 6.3.2.-) | protein | 87 | 62% helix, 1% strand | Q8RSY1 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 983 | 0.80 | 0.81 | 108 | empty |
| 2 | 1018 | 0.79 | 0.81 | 93 | empty |
| 3 | 555 | 0.73 | 0.81 | 60 | empty |
| 4 | 535 | 0.72 | 0.81 | 61 | empty |
| 5 | 325 | 0.69 | 0.83 | 37 | empty |
Interfaces
8 interfaces between chains.
- G–K · 1588 Ų buried · 19 hydrogen bonds · protein-protein
- D–F · 1481 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1420 Ų buried · 19 hydrogen bonds · protein-protein
- H–L · 1388 Ų buried · 19 hydrogen bonds · protein-protein
- G–H · 713 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (phosphorylation).
Compared structures
- 3TL8 · The AvrPtoB-BAK1 complex reveals two structurally similar kinaseinteracting domains in a… · the same entry in another collection · chain L against L, TM-score 1.00
- Q94F62 · AlphaFold monomer V2.0 prediction for brassinosteroid insensitive 1-associated receptor… · a predicted model of the same protein · chain H against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94F62
- Every structure of UniProt Q8RSY1
- Elsewhere: RCSB PDB 3TL8 · PDBe 3TL8 · UniProt Q94F62 · UniProt Q8RSY1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.