MolNFT v1 · #79957 · protein

Tubulin tyrosine ligase

3TII · Ttl protein: “Tubulin tyrosine ligase”. X-ray diffraction, 2 ligands (ANP, MG), 8 pockets (best druggability 0.63). MolNFT v1 #79957 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3TII
Type: protein
Length: 624 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ttl protein
UniProt: A9ULH4
Ligands: ANP, MG
Pockets: 8 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ttl protein	protein	311	30% helix, 22% strand	A9ULH4
B	Ttl protein	protein	313	29% helix, 23% strand	A9ULH4

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.63	0.80	49	empty
2	187	0.52	0.78	21	ANP, MG
3	150	0.48	0.77	19	ANP
4	50	0.47	0.85	18	empty
5	149	0.44	0.76	24	empty

Interfaces

1 interface between chains.

A–B · 786 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3TII · Tubulin tyrosine ligase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9ULH4
Elsewhere: RCSB PDB 3TII · PDBe 3TII · UniProt A9ULH4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.