MolNFT v1 · #79832 · protein
Crystal structure of an H-nox protein from T. tengcongensis
3TF0 · Methyl-accepting chemotaxis protein: “Crystal structure of an H-nox protein from T. tengcongensis”. X-ray diffraction, 2 ligands (HEM, OXY), 3 pockets (best druggability 0.81). MolNFT v1 #79832 on GenesisL1: 3D structure, binding…
- PDB
- 3TF0
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methyl-accepting chemotaxis protein
- UniProt
- Q8RBX6
- Ligands
- HEM, OXY
- Pockets
- 3 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methyl-accepting chemotaxis protein | protein | 186 | 49% helix, 21% strand | Q8RBX6 |
| B | Methyl-accepting chemotaxis protein | protein | 188 | 49% helix, 21% strand | Q8RBX6 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- OXY · Oxygen molecule · ion · 2 copies · chains A, B
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.81 | 0.91 | 35 | HEM, OXY, ACT |
| 2 | 321 | 0.81 | 0.91 | 38 | HEM, OXY |
| 3 | 508 | 0.62 | 0.75 | 55 | empty |
Interfaces
1 interface between chains.
- A–B · 275 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3TF0 · Crystal structure of an H-NOX protein from T. tengcongensis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RBX6
- Elsewhere: RCSB PDB 3TF0 · PDBe 3TF0 · UniProt Q8RBX6
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