MolNFT v1 · #7966 · protein

Structure of uree

1GMU: “Structure of uree”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #7966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1GMU
Type: protein
Length: 554 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uree
UniProt: P18317
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	Uree	protein	138	18% helix, 38% strand	P18317
C	Uree	protein	140	20% helix, 37% strand	P18317

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	756	0.74	0.80	59	empty
2	196	0.51	0.77	30	empty
3	110	0.35	0.73	21	empty

Interfaces

6 interfaces between chains.

A–B · 563 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 374 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 298 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 229 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 70 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1GMU · Structure of UreE · the same entry in another collection · chain A against A, TM-score 1.00
P18317 · AlphaFold monomer V2.0 prediction for urease accessory protein uree (P18317) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18317
Elsewhere: RCSB PDB 1GMU · PDBe 1GMU · UniProt P18317

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