MolNFT v1 · #7959 · protein
Crystal structure of the mouse cct gamma apical domain (triclinic)
1GML · T-complex protein 1 subunit gamma: “Crystal structure of the mouse cct gamma apical domain (triclinic)”. X-ray diffraction, 5 pockets (best druggability 0.53). MolNFT v1 #7959 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1GML
- Type
- protein
- Length
- 608 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-complex protein 1 subunit gamma
- UniProt
- P80318
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | T-complex protein 1 subunit gamma | protein | 154 | 30% helix, 32% strand | P80318 |
| B | T-complex protein 1 subunit gamma | protein | 152 | 30% helix, 31% strand | P80318 |
| D | T-complex protein 1 subunit gamma | protein | 148 | 30% helix, 32% strand | P80318 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 345 | 0.53 | 0.74 | 34 | empty |
| 2 | 51 | 0.44 | 0.84 | 15 | empty |
| 3 | 96 | 0.41 | 0.77 | 18 | GOL |
| 4 | 76 | 0.41 | 0.79 | 15 | GOL |
| 5 | 58 | 0.38 | 0.80 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–D · 831 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 817 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 302 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 26 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1GML · crystal structure of the mouse CCT gamma apical domain (triclinic) · the same entry in another collection · chain A against A, TM-score 1.00
- P80318 · AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit gamma (P80318) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P80318
- Elsewhere: RCSB PDB 1GML · PDBe 1GML · UniProt P80318
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