MolNFT v1 · #79318 · protein

Full-length structure of the vibrio cholerae virulence activator, aphb, a member of the lttr protein family

3SZP · Transcriptional regulator, lysr family: “Full-length structure of the vibrio cholerae virulence activator, aphb, a member of the lttr protein family”. X-ray diffraction, 4 pockets (best druggability 0.80). MolNFT v1 #79318 on…

PDB: 3SZP
Type: protein
Length: 578 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator, lysr family
UniProt: Q9KT56
Pockets: 4 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator, lysr family	protein	290	42% helix, 25% strand	Q9KT56
B	Transcriptional regulator, lysr family	protein	288	46% helix, 25% strand	Q9KT56

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1049	0.80	0.81	108	empty
2	63	0.54	0.88	21	empty
3	70	0.40	0.79	17	empty
4	74	0.30	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 1940 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

3SZP · Full-length structure of the Vibrio cholerae virulence activator, AphB, a member of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9KT56
Elsewhere: RCSB PDB 3SZP · PDBe 3SZP · UniProt Q9KT56

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