MolNFT v1 · #7926 · protein
Cation promoted association (cpa) of a regulatory and target protein is controlled by phosphorylation
1GLD · Glucose-specific protein iiiglc: “Cation promoted association (cpa) of a regulatory and target protein is controlled by phosphorylation”. X-ray diffraction, 3 ligands (G3H, ADP, MN), 6 pockets (best druggability 0.70). MolNFT v1…
- PDB
- 1GLD
- Type
- protein
- Length
- 650 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-specific protein iiiglc; Glycerol kinase
- EC
- 2.7.1.69, 2.7.1.30
- UniProt
- P69783, P0A6F3
- Ligands
- G3H, ADP, MN
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Glucose-specific protein iiiglc (EC 2.7.1.69) | protein | 161 | 12% helix, 38% strand | P69783 |
| G | Glycerol kinase (EC 2.7.1.30) | protein | 489 | 37% helix, 25% strand | P0A6F3 |
Ligands and binding sites
- G3H · Glyceraldehyde-3-phosphate · ligand · chains G
- ADP · Adenosine-5'-diphosphate · ligand · chains G
- MN · Manganese (II) ion · metal · chains G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 362 | 0.70 | 0.83 | 44 | MN, G3H, ADP |
| 2 | 143 | 0.55 | 0.81 | 21 | empty |
| 3 | 260 | 0.53 | 0.76 | 29 | empty |
| 4 | 84 | 0.38 | 0.77 | 19 | empty |
| 5 | 59 | 0.30 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- F–G · 626 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1GLD · Cation promoted association (cpa) of a regulatory and target protein is controlled by… · the same entry in another collection · chain F against F, TM-score 1.00
- P0A6F3 · AlphaFold monomer V2.0 prediction for glycerol kinase (P0A6F3) · a predicted model of the same protein · chain G against A, TM-score 0.98
- P69783 · AlphaFold monomer V2.0 prediction for pts system glucose-specific eiia component (P69783) · a predicted model of the same protein · chain F against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69783
- Every structure of UniProt P0A6F3
- Elsewhere: RCSB PDB 1GLD · PDBe 1GLD · UniProt P69783 · UniProt P0A6F3
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