MolNFT v1 · #79208 · protein

MUNC13-1, mun domain, C-terminal module

3SWH · Protein unc-13 homolog a: “MUNC13-1, mun domain, C-terminal module”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #79208 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3SWH
Type: protein
Length: 592 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein unc-13 homolog a
UniProt: Q62768
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein unc-13 homolog a	protein	295	80% helix, 0% strand	Q62768
B	Protein unc-13 homolog a	protein	297	80% helix, 1% strand	Q62768

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	274	0.53	0.75	29	empty
2	299	0.53	0.74	36	empty
3	83	0.41	0.78	20	empty
4	60	0.32	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 429 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3SWH · Munc13-1, MUN domain, C-terminal module · the same entry in another collection · chain A against A, TM-score 1.00
Q62768 · AlphaFold monomer V2.0 prediction for protein unc-13 homolog a (Q62768) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62768
Elsewhere: RCSB PDB 3SWH · PDBe 3SWH · UniProt Q62768

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