MolNFT v1 · #79070 · protein

Crystal structure of methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-ump

3SSJ · Orotidine 5'-phosphate decarboxylase: “Crystal structure of methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase…”. X-ray diffraction, 1 ligand (FNU), 2 pockets (best druggability 0.52). MolNFT v1 #79070…

PDB: 3SSJ
Type: protein
Length: 214 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Orotidine 5'-phosphate decarboxylase
EC: 4.1.1.23
UniProt: O26232
Ligands: FNU
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23)	protein	214	51% helix, 19% strand	O26232

Ligands and binding sites

FNU · 6-amino-5-fluorouridine 5'-(dihydrogen phosphate) · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.52	0.80	29	FNU
2	61	0.34	0.77	13	empty

Compared structures

3SSJ · Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O26232
Elsewhere: RCSB PDB 3SSJ · PDBe 3SSJ · UniProt O26232

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