MolNFT v1 · #79027 · protein

Crystal structure of mouse ptpsigma

3SR9 · Receptor-type tyrosine-protein phosphatase S: “Crystal structure of mouse ptpsigma”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #79027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3SR9
Type: protein
Length: 568 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase S
EC: 3.1.3.48
UniProt: B0V2N1
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase S (EC 3.1.3.48)	protein	568	32% helix, 22% strand	B0V2N1

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	423	0.78	0.87	47	empty
2	198	0.54	0.78	21	empty
3	171	0.49	0.77	19	empty
4	115	0.44	0.78	23	empty
5	129	0.41	0.75	22	empty

Compared structures

3SR9 · Crystal structure of mouse PTPsigma · the same entry in another collection · chain A against A, TM-score 1.00
B0V2N1 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase S… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0V2N1
Elsewhere: RCSB PDB 3SR9 · PDBe 3SR9 · UniProt B0V2N1

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