MolNFT v1 · #78975 · protein

Apo inward rectifier potassium channel KIR2.2 I223L mutant

3SPJ · Inward-rectifier K+ channel KIR2.2: “Apo inward rectifier potassium channel KIR2.2 I223L mutant”. X-ray diffraction, 1 ligand (K), 1 pocket (best druggability 0.32). MolNFT v1 #78975 on GenesisL1: 3D structure, binding sites and…

PDB: 3SPJ
Type: protein
Length: 321 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inward-rectifier K+ channel KIR2.2
UniProt: D2YW45
Ligands: K
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inward-rectifier K+ channel KIR2.2	protein	321	30% helix, 31% strand	D2YW45

Ligands and binding sites

K · Potassium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.32	0.74	23	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3SPJ · Apo inward rectifier potassium channel Kir2.2 I223L mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D2YW45
Elsewhere: RCSB PDB 3SPJ · PDBe 3SPJ · UniProt D2YW45

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