MolNFT v1 · #78974 · protein

Inward rectifier potassium channel KIR2.2 in complex with PIP2

3SPI · Inward-rectifier K+ channel KIR2.2: “Inward rectifier potassium channel KIR2.2 in complex with PIP2”. X-ray diffraction, 2 ligands (PIO, K), 2 pockets (best druggability 0.32). MolNFT v1 #78974 on GenesisL1: 3D structure, binding…

PDB: 3SPI
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inward-rectifier K+ channel KIR2.2
UniProt: D2YW45
Ligands: PIO, K
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inward-rectifier K+ channel KIR2.2	protein	332	33% helix, 27% strand	D2YW45

Ligands and binding sites

PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · ligand · chains A
K · Potassium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.32	0.75	16	empty
2	54	0.25	0.73	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3SPI · Inward rectifier potassium channel Kir2.2 in complex with PIP2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D2YW45
Elsewhere: RCSB PDB 3SPI · PDBe 3SPI · UniProt D2YW45

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.