MolNFT v1 · #78821 · protein
Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the flr peptide
3SKM · HLA class I histocompatibility antigen, B-8 alpha chain: “Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the flr peptide”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #78821 on GenesisL1: 3D structure…
- PDB
- 3SKM
- Type
- protein
- Length
- 378 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-8 alpha chain; Beta-2-microglobulin…
- UniProt
- P30460, P61769, Q3KST2
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-8 alpha chain | protein | 270 | 27% helix, 39% strand | P30460 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | Epstein-barr nuclear antigen 3 | protein | 9 | 0% helix, 0% strand | Q3KST2 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 551 | 0.65 | 0.76 | 55 | empty |
| 2 | 61 | 0.42 | 0.82 | 18 | empty |
| 3 | 83 | 0.38 | 0.77 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1315 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 952 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3SKM · Crystal structure of the HLA-B8FLRGRAYVL, mutant G8V of the FLR peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30460
- Every structure of UniProt P61769
- Every structure of UniProt Q3KST2
- Elsewhere: RCSB PDB 3SKM · PDBe 3SKM · UniProt P30460 · UniProt P61769 · UniProt Q3KST2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.