MolNFT v1 · #78674 · protein
Structure of the complex of streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8 ångströms resolution
3SGB · Proteinase B (sgpb): “Structure of the complex of streptomyces griseus protease B and the third domain of the turkey ovomucoid…”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #78674 on GenesisL1: 3D structure…
- PDB
- 3SGB
- Type
- protein
- Length
- 235 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteinase B (sgpb); Turkey ovomucoid inhibitor (OMTKY3)
- UniProt
- P00777, P68390
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Proteinase B (sgpb) | protein | 185 | 6% helix, 53% strand | P00777 |
| I | Turkey ovomucoid inhibitor (OMTKY3) | protein | 50 | 20% helix, 24% strand | P68390 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 136 | 0.43 | 0.76 | 23 | empty |
| 2 | 112 | 0.38 | 0.74 | 23 | empty |
Interfaces
1 interface between chains.
- E–I · 644 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 3SGB · Structure of the complex of streptomyces griseus protease B and the third domain of the… · the same entry in another collection · chain E against E, TM-score 1.00
- P00777 · AlphaFold monomer V2.0 prediction for streptogrisin-B (P00777) · a predicted model of the same protein · chain E against A, TM-score 0.99
- P68390 · AlphaFold monomer V2.0 prediction for ovomucoid (P68390) · a predicted model of the same protein · chain I against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00777
- Every structure of UniProt P68390
- Elsewhere: RCSB PDB 3SGB · PDBe 3SGB · UniProt P00777 · UniProt P68390
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