MolNFT v1 · #78636 · protein

Zn-mediated polymer of maltose-binding protein A216H/K220H by synthetic symmetrization (form I)

3SEW · Maltose-binding periplasmic protein: “Zn-mediated polymer of maltose-binding protein A216H/K220H by synthetic symmetrization (form I)”. X-ray diffraction, 3 ligands (GLC, ZN, CL), 3 pockets (best druggability 0.75). MolNFT v1 #78636…

PDB: 3SEW
Type: protein
Length: 370 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltose-binding periplasmic protein
UniProt: P0AEX9
Ligands: GLC, ZN, CL
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maltose-binding periplasmic protein	protein	370	45% helix, 21% strand	P0AEX9

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
ZN · Zinc ion · metal · chains A
CL · Chloride ion · ion · 4 copies · chains A
GOL · Glycerol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	253	0.75	0.88	26	GLC
2	62	0.38	0.79	16	empty
3	56	0.34	0.77	16	empty

Compared structures

3SEW · Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AEX9
Elsewhere: RCSB PDB 3SEW · PDBe 3SEW · UniProt P0AEX9

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