MolNFT v1 · #78624 · protein
Crystal structure of the MYOSTATIN:FOLLISTATIN-like 3 complex
3SEK · GROWTH/DIFFERENTIATION factor 8: “Crystal structure of the MYOSTATIN:FOLLISTATIN-like 3 complex”. X-ray diffraction, 1 ligand (NAG), 3 pockets (best druggability 0.68). MolNFT v1 #78624 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3SEK
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GROWTH/DIFFERENTIATION factor 8; Follistatin-related protein 3
- UniProt
- O08689, O95633
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | GROWTH/DIFFERENTIATION factor 8 | protein | 109 | 7% helix, 44% strand | O08689 |
| C | Follistatin-related protein 3 | protein | 201 | 15% helix, 24% strand | O95633 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 628 | 0.68 | 0.77 | 73 | empty |
| 2 | 66 | 0.47 | 0.84 | 17 | empty |
| 3 | 56 | 0.34 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- B–C · 1544 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 3SEK · Crystal Structure of the Myostatin:Follistatin-like 3 Complex · the same entry in another collection · chain B against B, TM-score 1.00
- O95633 · AlphaFold monomer V2.0 prediction for follistatin-related protein 3 (O95633) · a predicted model of the same protein · chain C against A, TM-score 0.98
- O08689 · AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 8 (O08689) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08689
- Every structure of UniProt O95633
- Elsewhere: RCSB PDB 3SEK · PDBe 3SEK · UniProt O08689 · UniProt O95633
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