MolNFT v1 · #78610 · protein
Human ifnw-ifnar ternary complex
3SE4 · Interferon ALPHA/BETA receptor 1: “Human ifnw-ifnar ternary complex”. X-ray diffraction, 1 ligand (NAG), 9 pockets (best druggability 0.58). MolNFT v1 #78610 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3SE4
- Type
- protein
- Length
- 618 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon ALPHA/BETA receptor 1; Interferon omega-1; Interferon ALPHA/BETA receptor 2
- UniProt
- P17181, P05000, P48551
- Ligands
- NAG
- Pockets
- 9 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon ALPHA/BETA receptor 1 | protein | 285 | 5% helix, 48% strand | P17181 |
| B | Interferon omega-1 | protein | 143 | 66% helix, 0% strand | P05000 |
| C | Interferon ALPHA/BETA receptor 2 | protein | 190 | 2% helix, 48% strand | P48551 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 362 | 0.58 | 0.75 | 47 | empty |
| 2 | 276 | 0.53 | 0.75 | 35 | empty |
| 3 | 205 | 0.53 | 0.78 | 31 | empty |
| 4 | 118 | 0.49 | 0.80 | 16 | empty |
| 5 | 99 | 0.42 | 0.78 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1139 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 976 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3SE4 · human IFNw-IFNAR ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
- P05000 · AlphaFold monomer V2.0 prediction for interferon omega-1 (P05000) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P17181 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 1 (P17181) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P48551 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 2 (P48551) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17181
- Every structure of UniProt P05000
- Every structure of UniProt P48551
- Elsewhere: RCSB PDB 3SE4 · PDBe 3SE4 · UniProt P17181 · UniProt P05000 · UniProt P48551
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