MolNFT v1 · #78302 · protein

Structure of a Y DNA-fanci complex

3S4Z · DNA repair 1: “Structure of a Y DNA-fanci complex”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #78302 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3S4Z
Type: protein
Length: 3,393 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA repair 1
UniProt: Q8K368
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	DNA repair 1	protein	1131	73% helix, 1% strand	Q8K368

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	889	0.80	0.82	113	empty
2	97	0.77	0.97	26	empty
3	836	0.76	0.80	64	empty
4	91	0.75	0.96	27	empty
5	59	0.73	0.98	18	empty

Interfaces

2 interfaces between chains.

B–C · 1310 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 552 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3S4Z · Structure of a Y DNA-FANCI complex · the same entry in another collection · chain A against A, TM-score 1.00
Q8K368 · AlphaFold monomer V2.0 prediction for fanconi anemia group I protein homolog (Q8K368) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K368
Elsewhere: RCSB PDB 3S4Z · PDBe 3S4Z · UniProt Q8K368

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