MolNFT v1 · #78299 · protein
Structure of the fanci-FANCD2 complex
3S4W · Fanconi anemia group I protein homolog: “Structure of the fanci-FANCD2 complex”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #78299 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3S4W
- Type
- protein
- Length
- 2,352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fanconi anemia group I protein homolog; Fanconi anemia group D2 protein homolog
- UniProt
- Q8K368, Q80V62
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fanconi anemia group I protein homolog | protein | 1206 | 70% helix, 1% strand | Q8K368 |
| B | Fanconi anemia group D2 protein homolog | protein | 1146 | 70% helix, 1% strand | Q80V62 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 833 | 0.80 | 0.83 | 101 | empty |
| 2 | 724 | 0.78 | 0.83 | 68 | empty |
| 3 | 980 | 0.77 | 0.79 | 99 | empty |
| 4 | 505 | 0.76 | 0.84 | 52 | empty |
| 5 | 1004 | 0.73 | 0.76 | 88 | empty |
Interfaces
1 interface between chains.
- A–B · 3637 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 3S4W · Structure of the FANCI-FANCD2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q80V62 · AlphaFold monomer V2.0 prediction for fanconi anemia group D2 protein homolog (Q80V62) · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q8K368 · AlphaFold monomer V2.0 prediction for fanconi anemia group I protein homolog (Q8K368) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K368
- Every structure of UniProt Q80V62
- Elsewhere: RCSB PDB 3S4W · PDBe 3S4W · UniProt Q8K368 · UniProt Q80V62
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