MolNFT v1 · #7829 · protein

Refined three-dimensional structure of the Fab fragment of a murine IGG1, lambda antibody

1GIG · IGG1-kappa HC19 Fab (light chain): “Refined three-dimensional structure of the Fab fragment of a murine IGG1, lambda antibody”. X-ray diffraction, 4 pockets (best druggability 0.47). MolNFT v1 #7829 on GenesisL1: 3D structure…

PDB: 1GIG
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: IGG1-kappa HC19 Fab (light chain); IGG1-kappa HC19 Fab (heavy chain)
Pockets: 4 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	IGG1-kappa HC19 Fab (light chain)	protein	210	8% helix, 55% strand	—
H	IGG1-kappa HC19 Fab (heavy chain)	protein	221	3% helix, 51% strand	—

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	220	0.47	0.74	31	empty
2	138	0.45	0.77	23	empty
3	69	0.39	0.79	21	empty
4	50	0.24	0.72	15	empty

Interfaces

1 interface between chains.

L–H · 1781 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1GIG · Refined three-dimensional structure of the Fab fragment of a murine IGG1, lambda antibody · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1GIG · PDBe 1GIG

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