MolNFT v1 · #78166 · protein
The crystal structure of gxgd membrane protease flak
3S0X · Peptidase A24B, flak domain protein: “The crystal structure of gxgd membrane protease flak”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #78166 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3S0X
- Type
- protein
- Length
- 411 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidase A24B, flak domain protein
- UniProt
- A9A677
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidase A24B, flak domain protein | protein | 225 | 60% helix, 6% strand | A9A677 |
| B | Peptidase A24B, flak domain protein | protein | 186 | 71% helix, 0% strand | A9A677 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1055 | 0.76 | 0.78 | 70 | empty |
| 2 | 286 | 0.59 | 0.78 | 47 | empty |
| 3 | 57 | 0.53 | 0.88 | 20 | empty |
| 4 | 98 | 0.44 | 0.79 | 19 | empty |
| 5 | 72 | 0.29 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 598 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A9A677
- Elsewhere: RCSB PDB 3S0X · PDBe 3S0X · UniProt A9A677
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