MolNFT v1 · #78026 · protein
Rhesus macaque MHC class I molecule mamu-B*17-GW10
3RWI · Major histocompatibility complex class I: “Rhesus macaque MHC class I molecule mamu-B*17-GW10”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #78026 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3RWI
- Type
- protein
- Length
- 385 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major histocompatibility complex class I; Beta-2-microglobulin; Vif GW10 peptide from…
- UniProt
- Q9GJ77, Q6V7J5, Q89490
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major histocompatibility complex class I | protein | 276 | 27% helix, 40% strand | Q9GJ77 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | Q6V7J5 |
| C | Vif GW10 peptide from virion infectivity factor | protein | 10 | 0% helix, 0% strand | Q89490 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 619 | 0.67 | 0.77 | 51 | empty |
| 2 | 123 | 0.47 | 0.79 | 19 | empty |
| 3 | 61 | 0.42 | 0.81 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1365 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 1034 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GJ77
- Every structure of UniProt Q6V7J5
- Every structure of UniProt Q89490
- Elsewhere: RCSB PDB 3RWI · PDBe 3RWI · UniProt Q9GJ77 · UniProt Q6V7J5 · UniProt Q89490
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.