MolNFT v1 · #77806 · protein
Crystal structure of complement component 1, Q subcomponent binding protein, C1QBP
3RPX · Complement component 1 Q subcomponent-binding protein: “Crystal structure of complement component 1, Q subcomponent binding protein, C1QBP”. X-ray diffraction, 1 ligand (UNX), 2 pockets (best druggability 0.32). MolNFT v1 #77806 on…
- PDB
- 3RPX
- Type
- protein
- Length
- 422 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement component 1 Q subcomponent-binding protein
- UniProt
- Q07021
- Ligands
- UNX
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement component 1 Q subcomponent-binding protein | protein | 148 | 32% helix, 32% strand | Q07021 |
| B | Complement component 1 Q subcomponent-binding protein | protein | 141 | 33% helix, 32% strand | Q07021 |
| C | Complement component 1 Q subcomponent-binding protein | protein | 133 | 35% helix, 35% strand | Q07021 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 19 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.32 | 0.76 | 13 | empty |
| 2 | 54 | 0.29 | 0.75 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–C · 930 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 782 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 773 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3RPX · Crystal structure of complement component 1, q subcomponent binding protein, C1QBP · the same entry in another collection · chain A against A, TM-score 1.00
- Q07021 · AlphaFold monomer V2.0 prediction for complement component 1 Q subcomponent-binding… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07021
- Elsewhere: RCSB PDB 3RPX · PDBe 3RPX · UniProt Q07021
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