MolNFT v1 · #77783 · protein

Crystal structure of the apo MAPK from toxoplasma gondii, 25.M01780 or TGME49_007820

3RP9 · Mitogen-activated protein kinase: “Crystal structure of the apo MAPK from toxoplasma gondii, 25.M01780 or TGME49_007820”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.56). MolNFT v1 #77783 on GenesisL1: 3D…

PDB: 3RP9
Type: protein
Length: 350 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase
EC: 2.7.11.24
UniProt: B6KP12
Ligands: SO4
Pockets: 5 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitogen-activated protein kinase (EC 2.7.11.24)	protein	350	37% helix, 10% strand	B6KP12

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.56	0.79	28	empty
2	151	0.46	0.77	28	SO4
3	157	0.42	0.74	19	empty
4	75	0.38	0.77	16	empty
5	83	0.37	0.76	21	empty

Compared structures

3RP9 · Crystal Structure of the apo MapK from Toxoplasma Gondii, 25.m01780 or TGME49_007820 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B6KP12
Elsewhere: RCSB PDB 3RP9 · PDBe 3RP9 · UniProt B6KP12

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