MolNFT v1 · #77528 · protein

Crystal structure of the C707A mutant of the C-terminal domain of 10'FORMYLTETRAHYDROFOLATE dehydrogenase

3RHP · Aldehyde dehydrogenase 1 family, member L1: “Crystal structure of the C707A mutant of the C-terminal domain of 10'FORMYLTETRAHYDROFOLATE dehydrogenase”. X-ray diffraction, 1 ligand (SO4), 20 pockets (best druggability 0.86). MolNFT…

PDB: 3RHP
Type: protein
Length: 1,992 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aldehyde dehydrogenase 1 family, member L1
UniProt: Q5HZB2
Ligands: SO4
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Aldehyde dehydrogenase 1 family, member L1	protein	498	42% helix, 23% strand	Q5HZB2

Ligands and binding sites

SO4 · Sulfate ion · ion · 24 copies · chains A, B, C, D
GOL · Glycerol · additive · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	526	0.86	0.92	63	SO4
2	407	0.83	0.91	50	SO4
3	806	0.82	0.85	62	SO4
4	436	0.81	0.89	35	SO4
5	403	0.80	0.89	35	SO4

Interfaces

6 interfaces between chains.

C–D · 2613 Å² buried · 39 hydrogen bonds · protein-protein
A–B · 2578 Å² buried · 42 hydrogen bonds · protein-protein
B–D · 1277 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 1265 Å² buried · 18 hydrogen bonds · protein-protein
B–C · 1145 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3RHP · Crystal structure of the C707A mutant of the C-Terminal domain of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5HZB2
Elsewhere: RCSB PDB 3RHP · PDBe 3RHP · UniProt Q5HZB2

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