MolNFT v1 · #77521 · protein

DNA-binding protein hu from bacillus anthracis

3RHI: “DNA-binding protein hu from bacillus anthracis”. X-ray diffraction, 2 pockets (best druggability 0.59). MolNFT v1 #77521 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3RHI
Type: protein
Length: 348 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-binding protein hu
UniProt: E9QVF3
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 4 distinct chains · 44% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-binding protein hu	protein	87	43% helix, 31% strand	E9QVF3
B	DNA-binding protein hu	protein	89	44% helix, 24% strand	E9QVF3
C	DNA-binding protein hu	protein	90	43% helix, 30% strand	E9QVF3
D	DNA-binding protein hu	protein	82	46% helix, 23% strand	E9QVF3

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.59	0.78	37	empty
2	114	0.35	0.73	20	empty

Interfaces

6 interfaces between chains.

C–D · 1827 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1738 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 456 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 292 Å² buried · 5 hydrogen bonds · protein-protein
B–D · 290 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3RHI · DNA-binding protein HU from Bacillus anthracis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9QVF3
Elsewhere: RCSB PDB 3RHI · PDBe 3RHI · UniProt E9QVF3

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