MolNFT v1 · #77351 · protein + RNA
Human mitochondrial helicase SUV3 in complex with short RNA fragment
3RC8 · ATP-dependent RNA helicase SUPV3L1, mitochondrial: “Human mitochondrial helicase SUV3 in complex with short RNA fragment”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #77351 on GenesisL1: 3D structure, binding…
- PDB
- 3RC8
- Type
- protein + RNA
- Length
- 615 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase SUPV3L1, mitochondrial; RNA fragment
- EC
- 3.6.4.13
- UniProt
- Q8IYB8
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) | protein | 610 | 50% helix, 13% strand | Q8IYB8 |
| E | RNA fragment | rna | 5 | — | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 838 | 0.78 | 0.81 | 74 | empty |
| 2 | 584 | 0.76 | 0.83 | 61 | empty |
| 3 | 305 | 0.65 | 0.81 | 34 | empty |
| 4 | 51 | 0.50 | 0.87 | 15 | empty |
| 5 | 107 | 0.43 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–E · 712 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 3RC8 · Human Mitochondrial Helicase Suv3 in Complex with Short RNA Fragment · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IYB8 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase SUPV3L1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IYB8
- Elsewhere: RCSB PDB 3RC8 · PDBe 3RC8 · UniProt Q8IYB8
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