MolNFT v1 · #77284 · protein
Structural studies of AAV8 capsid transitions associated with endosomal trafficking
3RA8 · Capsid protein: “Structural studies of AAV8 capsid transitions associated with endosomal trafficking”. X-ray diffraction, 1 ligand (A), 6 pockets (best druggability 0.61). MolNFT v1 #77284 on GenesisL1: 3D structure, binding sites…
- PDB
- 3RA8
- Type
- protein
- Length
- 519 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein
- UniProt
- Q8JQF8
- Ligands
- A
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Capsid protein | protein | 519 | 8% helix, 34% strand | Q8JQF8 |
Ligands and binding sites
- A · Adenosine-5'-monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.61 | 0.75 | 57 | empty |
| 2 | 287 | 0.60 | 0.79 | 46 | empty |
| 3 | 203 | 0.46 | 0.74 | 29 | empty |
| 4 | 150 | 0.41 | 0.74 | 25 | empty |
| 5 | 92 | 0.38 | 0.76 | 27 | A |
Compared structures
- 3RA8 · Structural studies of AAV8 capsid transitions associated with endosomal trafficking · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JQF8
- Elsewhere: RCSB PDB 3RA8 · PDBe 3RA8 · UniProt Q8JQF8
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