MolNFT v1 · #77061 · protein
Crystal structure of O-methyltransferase from legionella pneumophila
3R3H · O-methyltransferase, SAM-dependent: “Crystal structure of O-methyltransferase from legionella pneumophila”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #77061 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3R3H
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-methyltransferase, SAM-dependent
- EC
- 2.1.1.-
- UniProt
- Q5ZT85
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | O-methyltransferase, SAM-dependent (EC 2.1.1.-) | protein | 217 | 42% helix, 21% strand | Q5ZT85 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 651 | 0.70 | 0.78 | 81 | empty |
| 2 | 120 | 0.39 | 0.75 | 27 | empty |
| 3 | 75 | 0.38 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2335 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3R3H · Crystal structure of O-methyltransferase from Legionella pneumophila · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZT85
- Elsewhere: RCSB PDB 3R3H · PDBe 3R3H · UniProt Q5ZT85
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