MolNFT v1 · #77001 · protein
Odorant binding protein 7 from anopheles gambiae with four disulfide bridges, form P1
3R1P · Odorant binding protein, antennal: “Odorant binding protein 7 from anopheles gambiae with four disulfide bridges, form P1”. X-ray diffraction, 1 ligand (PLM), 7 pockets (best druggability 0.85). MolNFT v1 #77001 on GenesisL1: 3D…
- PDB
- 3R1P
- Type
- protein
- Length
- 646 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Odorant binding protein, antennal
- UniProt
- Q7PXT9
- Ligands
- PLM
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 5 distinct chains · 65% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Odorant binding protein, antennal | protein | 108 | 64% helix, 2% strand | Q7PXT9 |
| B | Odorant binding protein, antennal | protein | 107 | 66% helix, 2% strand | Q7PXT9 |
| C, D | Odorant binding protein, antennal | protein | 110 | 65% helix, 2% strand | Q7PXT9 |
| E | Odorant binding protein, antennal | protein | 105 | 65% helix, 2% strand | Q7PXT9 |
| F | Odorant binding protein, antennal | protein | 106 | 64% helix, 2% strand | Q7PXT9 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 868 | 0.85 | 0.86 | 96 | PLM |
| 2 | 249 | 0.80 | 0.91 | 27 | PLM |
| 3 | 242 | 0.78 | 0.90 | 26 | PLM |
| 4 | 320 | 0.76 | 0.87 | 39 | PLM |
| 5 | 358 | 0.76 | 0.86 | 50 | PLM |
Interfaces
10 interfaces between chains.
- B–E · 428 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 425 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 401 Ų buried · 2 hydrogen bonds · protein-protein
- C–F · 401 Ų buried · 2 hydrogen bonds · protein-protein
- D–E · 365 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 3R1P · Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, form P1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7PXT9
- Elsewhere: RCSB PDB 3R1P · PDBe 3R1P · UniProt Q7PXT9
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