MolNFT v1 · #76949 · protein
Crystal structure of anti-mouse CD3EPSILON antibody 2C11 Fab fragment
3R06 · Anti-mouse CD3EPSILON antibody 2C11 Fab light chain: “Crystal structure of anti-mouse CD3EPSILON antibody 2C11 Fab fragment”. X-ray diffraction, 20 pockets (best druggability 0.65). MolNFT v1 #76949 on GenesisL1: 3D structure…
- PDB
- 3R06
- Type
- protein
- Length
- 1,695 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-mouse CD3EPSILON antibody 2C11 Fab light chain; Anti-mouse CD3EPSILON antibody 2C11…
- Pockets
- 20 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, L | Anti-mouse CD3EPSILON antibody 2C11 Fab light chain | protein | 213 | 6% helix, 52% strand | — |
| B | Anti-mouse CD3EPSILON antibody 2C11 Fab heavy chain | protein | 210 | 7% helix, 53% strand | — |
| D, F, H | Anti-mouse CD3EPSILON antibody 2C11 Fab heavy chain | protein | 211 | 7% helix, 54% strand | — |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.65 | 0.77 | 38 | empty |
| 2 | 479 | 0.58 | 0.74 | 46 | empty |
| 3 | 316 | 0.55 | 0.76 | 36 | empty |
| 4 | 229 | 0.54 | 0.77 | 37 | empty |
| 5 | 210 | 0.53 | 0.78 | 27 | empty |
Interfaces
9 interfaces between chains.
- E–F · 1840 Ų buried · 15 hydrogen bonds · protein-protein
- H–L · 1798 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1794 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1785 Ų buried · 16 hydrogen bonds · protein-protein
- C–H · 289 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 3R06 · Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3R06 · PDBe 3R06
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