MolNFT v1 · #76862 · protein
Crystal structure of the CDC25 domain from ral-specific guanine- nucleotide exchange factor RALGPS1A
3QXL · RAS-specific guanine nucleotide-releasing factor RALGPS1: “Crystal structure of the CDC25 domain from ral-specific guanine- nucleotide exchange factor RALGPS1A”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1…
- PDB
- 3QXL
- Type
- protein
- Length
- 489 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-specific guanine nucleotide-releasing factor RALGPS1
- UniProt
- Q5JS13
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-specific guanine nucleotide-releasing factor RALGPS1 | protein | 245 | 73% helix, 1% strand | Q5JS13 |
| B | RAS-specific guanine nucleotide-releasing factor RALGPS1 | protein | 244 | 72% helix, 1% strand | Q5JS13 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1046 | 0.77 | 0.79 | 82 | empty |
| 2 | 174 | 0.57 | 0.81 | 30 | empty |
| 3 | 129 | 0.43 | 0.76 | 19 | empty |
| 4 | 80 | 0.34 | 0.75 | 16 | empty |
| 5 | 68 | 0.32 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 739 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3QXL · Crystal structure of the CDC25 Domain from Ral-specific Guanine-nucleotide Exchange… · the same entry in another collection · chain A against A, TM-score 1.00
- Q5JS13 · AlphaFold monomer V2.0 prediction for RAS-specific guanine nucleotide-releasing factor… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JS13
- Elsewhere: RCSB PDB 3QXL · PDBe 3QXL · UniProt Q5JS13
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