MolNFT v1 · #76726 · protein
Structure of S. pombe nuclear import adaptor NRO1 (space group P21)
3QTM · Uncharacterized protein C4B3.07: “Structure of S. pombe nuclear import adaptor NRO1 (space group P21)”. X-ray diffraction, 2 ligands (SO4, CL), 5 pockets (best druggability 0.69). MolNFT v1 #76726 on GenesisL1: 3D structure, binding…
- PDB
- 3QTM
- Type
- protein
- Length
- 657 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein C4B3.07
- UniProt
- Q9USJ7
- Ligands
- SO4, CL
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein C4B3.07 | protein | 329 | 77% helix, 0% strand | Q9USJ7 |
| B | Uncharacterized protein C4B3.07 | protein | 328 | 79% helix, 0% strand | Q9USJ7 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 479 | 0.69 | 0.80 | 48 | empty |
| 2 | 225 | 0.55 | 0.78 | 34 | empty |
| 3 | 196 | 0.53 | 0.78 | 30 | empty |
| 4 | 63 | 0.35 | 0.78 | 13 | empty |
| 5 | 50 | 0.28 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1216 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered, artifact).
Compared structures
- 3QTM · Structure of S. pombe nuclear import adaptor Nro1 (Space group P21) · the same entry in another collection · chain B against B, TM-score 1.00
- Q9USJ7 · AlphaFold monomer V2.0 prediction for negative regulator of OFD1 (Q9USJ7) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9USJ7
- Elsewhere: RCSB PDB 3QTM · PDBe 3QTM · UniProt Q9USJ7
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