MolNFT v1 · #76538 · protein

Orthorhombic form of human IGA1 Fab fragment, sharing same fv as IgG

3QNX · Fab fragment of immunoglobulin A1 light chain: “Orthorhombic form of human IGA1 Fab fragment, sharing same fv as IgG”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #76538 on GenesisL1: 3D structure, binding sites…

PDB: 3QNX
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab fragment of immunoglobulin A1 light chain; Fab fragment of immunoglobulin A1 heavy…
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fab fragment of immunoglobulin A1 light chain	protein	219	5% helix, 50% strand	—
B	Fab fragment of immunoglobulin A1 heavy chain	protein	219	4% helix, 51% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	561	0.64	0.76	70	empty
2	108	0.36	0.73	24	GOL
3	65	0.29	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 1662 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3QNX · Orthorhombic form of human IgA1 Fab fragment, sharing same Fv as IgG · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3QNX · PDBe 3QNX

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