MolNFT v1 · #76516 · protein

Crystal structure of a 6-pyruvoyltetrahydropterin synthase homologue from esherichia COLI

3QN9 · 6-pyruvoyl tetrahydrobiopterin synthase: “Crystal structure of a 6-pyruvoyltetrahydropterin synthase homologue from esherichia COLI”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.40). MolNFT v1 #76516 on…

PDB: 3QN9
Type: protein
Length: 235 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 6-pyruvoyl tetrahydrobiopterin synthase
EC: 4.2.3.12
UniProt: C6EJA7
Ligands: ZN
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	protein	118	30% helix, 34% strand	C6EJA7
B	6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)	protein	117	27% helix, 31% strand	C6EJA7

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.40	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 740 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

3QN9 · Crystal structure of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C6EJA7
Elsewhere: RCSB PDB 3QN9 · PDBe 3QN9 · UniProt C6EJA7

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