MolNFT v1 · #75986 · protein
Structure of dually-phosphorylated met receptor kinase in complex with an mk-2461 analog with specificity for the activated receptor
3Q6W · Hepatocyte growth factor receptor: “Structure of dually-phosphorylated met receptor kinase in complex with an mk-2461 analog with specificity for…”. X-ray diffraction, 1 ligand (Q6W), 3 pockets (best druggability 0.60). MolNFT v1…
- PDB
- 3Q6W
- Type
- protein
- Length
- 299 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P08581
- Ligands
- Q6W
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatocyte growth factor receptor (EC 2.7.10.1) | protein | 299 | 39% helix, 18% strand | P08581 |
Ligands and binding sites
- Q6W · 3-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)propanamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.60 | 0.83 | 25 | Q6W |
| 2 | 133 | 0.39 | 0.74 | 26 | empty |
| 3 | 62 | 0.29 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 3Q6W · Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08581
- Elsewhere: RCSB PDB 3Q6W · PDBe 3Q6W · UniProt P08581
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